US Naval Research Laboratory, Optical Sciences Division, Washington, DC 20375, USA.
J Colloid Interface Sci. 2012 Jun 15;376(1):107-11. doi: 10.1016/j.jcis.2012.03.033. Epub 2012 Mar 20.
We describe a new, single pot, aqueous phase method for synthesizing water soluble gold nanoparticles (AuNPs) over a size range of 15-130 nm. Poly(ethylene glycol)-appended thioctic acid ligands were used to control the growth rates and stabilize the AuNPs. Critical factors that enable the controlled growth of the AuNPs over this size range include the pH, the choice of reducing agent, the reaction temperature and the sequential addition of gold precursor and ligand with specific ligand-to-gold ratios. We describe the synthetic procedure in detail. Optical and structural characterization of the AuNPs was accomplished using UV-vis absorption spectroscopy, dynamic light scattering, and transmission and scanning electron microscopy.
我们描述了一种新的、单锅、水相方法，用于合成尺寸范围在 15-130nm 的水溶性金纳米粒子（AuNPs）。聚（乙二醇）-接枝硫辛酸配体用于控制生长速率并稳定 AuNPs。能够在这个尺寸范围内控制 AuNPs 生长的关键因素包括 pH 值、还原剂的选择、反应温度以及金前体和配体的顺序添加，具有特定的配体与金的比例。我们详细描述了合成步骤。使用紫外-可见吸收光谱、动态光散射以及透射和扫描电子显微镜对 AuNPs 的光学和结构特性进行了表征。
