Wang Yi, Chen Hai-Bin, Zhang Ling, Zhang Li-Ying, Liu Jing-Cheng, Wang Zheng-Guo
State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Chin J Traumatol. 2012;15(2):67-76.
To investigate the material properties of normal and degenerated intervertebral discs (IVDs) and examine the effect of degenerative changes on IVD pathology.
A computer-based online search was undertaken to identify English articles about material properties of IVDs published from January 1950 to 2011 in PubMed database. The retrieved keywords included material properties, intervertebral disc and degeneration. Based on the principles of reliability, advancement and efficiency, the obtained data were primarily examined, and the original source was retrieved to read the full-text. Repetitive articles were excluded. The data of material properties of normal and degenerated IVDs were summarized and analyzed by meta-analysis.
The data of Young's modulus, Poisson's ratio, shear modulus, hydraulic permeability and intradiscal pressure of normal and degenerated IVDs were obtained. Compared with normal IVDs, the Young's modulus and shear modulus of annulus fibrosus and nucleus pulposus were higher in degenerated IVDs, the Poisson's ratio was lower while the hydraulic permeability and intradiscal pressure were higher. Besides, the degeneration-related alterations in IVDs had an influence both on itself and other spinal structures, leading to diseases such as bulging disc, discogenic pain and spinal stenosis. Meanwhile, the heavy mechanical loading and injury indicated important pathways to IVD degeneration.
To a certain extent, the degenerative changes of IVD influence its material properties. And the degeneration-related alterations of composition can cause structural failure of IVDs, leading to injuries and diseases.
研究正常和退变椎间盘（IVD）的材料特性，并探讨退变对IVD病理的影响。
通过计算机在线检索，在PubMed数据库中查找1950年1月至2011年发表的关于IVD材料特性的英文文章。检索关键词包括材料特性、椎间盘和退变。根据可靠性、先进性和有效性原则，对获取的数据进行初步筛选，并检索原始文献阅读全文。排除重复文章。采用Meta分析对正常和退变IVD的材料特性数据进行总结和分析。
获取了正常和退变IVD的杨氏模量、泊松比、剪切模量、水渗透率和椎间盘内压力的数据。与正常IVD相比，退变IVD中纤维环和髓核的杨氏模量和剪切模量较高，泊松比降低，而水渗透率和椎间盘内压力较高。此外，IVD的退变相关改变对其自身和其他脊柱结构均有影响，可导致椎间盘膨出、椎间盘源性疼痛和椎管狭窄等疾病。同时，重度机械负荷和损伤是IVD退变的重要途径。
IVD的退变在一定程度上影响其材料特性。退变相关的成分改变可导致IVD结构破坏，进而引发损伤和疾病。
