O'Brien C P, Childress A R, McLellan T, Ehrman R
Addiction Research Center, University of Pennsylvania, Philadelphia 19104.
Addict Behav. 1990;15(4):355-65. doi: 10.1016/0306-4603(90)90045-y.
Repeated drug administration readily produces classically conditioned responses in animal and human experimental studies. The majority of patients applying for treatment of drug dependence show both autonomic and subjective responses when exposed to drug-related stimuli. These responses are presumed to have been conditioned during a period of active drug use, persist after traditional treatment for drug dependence, and may constitute one of several factors which predispose to relapse. Preliminary data are presented from a novel treatment approach which is designed to test whether drug-conditioned responses can be reduced or extinguished by systematic exposure to drug-related cues and whether such extinction improves the overall results of treatment.
在动物和人体实验研究中，重复给药很容易产生经典条件反射反应。大多数申请药物依赖治疗的患者在接触与药物相关的刺激时会表现出自主和主观反应。这些反应被认为是在积极使用药物期间形成的条件反射，在传统的药物依赖治疗后仍然存在，并且可能是导致复发的几个因素之一。本文展示了一种新治疗方法的初步数据，该方法旨在测试通过系统暴露于与药物相关的线索是否可以减少或消除药物条件反应，以及这种消退是否能改善治疗的总体效果。
