血清脂质过氧化物作为足月新生儿缺氧缺血性脑病诊断试验的有用性。
Usefulness of serum lipid peroxide as a diagnostic test for hypoxic ischemic encephalopathy in the full-term neonate.
机构信息
UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Hospital Materno Infantil Esperanza López Mateos, Secretaria de Salud Jalisco, Guadalajara, Mexico.
出版信息
J Perinatol. 2013 Jan;33(1):15-20. doi: 10.1038/jp.2012.38. Epub 2012 Apr 5.
OBJECTIVE
To evaluate the usefulness of serum lipid peroxide (LPO) for hypoxic ischemic encephalopathy (HIE) in full-term neonates.
STUDY DESIGN
Diagnostic test evaluation forming three groups: (1) healthy full-term neonates (n=59), (2) at-risk full-term neonates without HIE (n=57) and (3) at-risk full-term neonates with HIE (n=57). HIE diagnosis was made using the Finer clinical classification at 48 h after birth. Serum LPO was taken at 4 h after birth and determined by spectrophotometry.
RESULT
One hundred seventy-three full-term neonates were studied. Fifty-one of the at-risk full-term neonates with HIE (51/57) had high serum LPO and two of the at-risk full-term neonates without HIE (2/57) (P<0.001). Serum LPO level had 89% sensitivity, 96% specificity, 96% positive predictive value, 90% negative predictive value, 24 positive probability ratio, 0.11 negative probability ratio and 92% diagnostic usefulness.
CONCLUSION
Serum LPO level could be a useful test for early diagnosis of HIE in full-term neonates.
目的
评估血清脂质过氧化物（LPO）在足月新生儿缺氧缺血性脑病（HIE）中的应用价值。
研究设计
形成三组的诊断试验评估：（1）健康足月新生儿（n=59），（2）无 HIE 风险的足月新生儿（n=57）和（3）有 HIE 风险的足月新生儿（n=57）。HIE 诊断采用出生后 48 小时的 Finer 临床分类。在出生后 4 小时采集血清 LPO，并通过分光光度法测定。
结果
共研究了 173 例足月新生儿。51 例有 HIE 风险的足月新生儿（51/57）血清 LPO 升高，2 例无 HIE 风险的足月新生儿（2/57）（P<0.001）。血清 LPO 水平的灵敏度为 89%，特异性为 96%，阳性预测值为 96%，阴性预测值为 90%，阳性似然比为 24，阴性似然比为 0.11，诊断有用性为 92%。
结论
血清 LPO 水平可能是足月新生儿 HIE 早期诊断的有用检测指标。
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