Macedo Rodrigo, Andretta Marianne, Albers Carolina, Skare Thelma, Ribas-Filho Jurandir Marcondes, Czeczko Nicolau Gregori
Evangelic Faculty of Paraná/ Evangelic University Hospital of Curitiba, PR, Brazil.
Rev Col Bras Cir. 2012;39(1):10-5. doi: 10.1590/s0100-69912012000100004.
To evaluate the intima-media thickness of the common carotid artery in patients with and without scleroderma; to verify a possible association with disease severity; to assess the relationship of intima-media thickness with known cardiovascular risk factors.
In a case-control study, were selected 30 patients with scleroderma and 30 without the disease and matched according to age, sex and cardiovascular risk factors such as hypertension, diabetes mellitus and hypercholesterolemia. The age ranged from 17 to 79 years (mean 49). All patients underwent carotid artery evaluation by high-resolution vascular Doppler in order to measure the intima-medial thickness of the carotid 2 cm from the bifurcation. In all the analysis was considered the greatest value of intima-media thickness in right and left carotid arteries.
The sample consisted of 30 patients, being 29 (96.67%) women and one man (3.3%). In this sample, 11/30 (36.67%) had high blood pressure, 5/30 (16.67%) had diabetes mellitus, 6/30 (20%) had dyslipidemia and 2/30 (6.67%) were smokers. Comparing the measure of the increased risk (maximum intima-media thickness between the left and right side), was obtained an average of 0.77 mm for group scleroderma and a value of 0.70 mm for the control group (p = 0.21). In assessing the association between disease severity and carotid intima-media thickness, was found no significant association (p= 0.925).
Was found a slight increase in intima-medial thickness of common carotid artery in patients with scleroderma but without statistical significance. Regarding the severity of the disease and intima-medial thickness of common carotid artery, there was no significant difference.
评估硬皮病患者和非硬皮病患者的颈总动脉内膜中层厚度；验证其与疾病严重程度之间可能存在的关联；评估内膜中层厚度与已知心血管危险因素之间的关系。
在一项病例对照研究中，选取了30例硬皮病患者和30例非硬皮病患者，并根据年龄、性别以及高血压、糖尿病和高胆固醇血症等心血管危险因素进行匹配。年龄范围为17至79岁（平均49岁）。所有患者均接受高分辨率血管多普勒检查以评估颈动脉，测量距分叉处2 cm的颈动脉内膜中层厚度。在所有分析中，均采用左右颈动脉内膜中层厚度的最大值。
样本包括30例患者，其中29例（96.67%）为女性，1例（3.3%）为男性。在该样本中，11/30（36.67%）患有高血压，5/30（16.67%）患有糖尿病，6/30（20%）患有血脂异常，2/30（6.67%）为吸烟者。比较风险增加的测量值（左右两侧内膜中层厚度的最大值），硬皮病组的平均值为0.77 mm，对照组为0.70 mm（p = 0.21）。在评估疾病严重程度与颈动脉内膜中层厚度之间的关联时，未发现显著关联（p = 0.925）。
硬皮病患者颈总动脉内膜中层厚度略有增加，但无统计学意义。关于疾病严重程度与颈总动脉内膜中层厚度，未发现显著差异。
