Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Sweden.
Thromb Res. 2012 Sep;130(3):339-42. doi: 10.1016/j.thromres.2012.03.016. Epub 2012 Apr 5.
The ABO blood group system is encoded by one gene, ABO. Previous studies have reported an association between blood group non-O (i.e. phenotype A, B or AB) and myocardial infarction. Studies on stroke and ABO are, however, more scarce. Therefore, we aimed to investigate whether ABO phenotype or genotype is associated with ischemic stroke and/or etiologic subtypes of ischemic stroke.
The study was performed in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), which comprises 600 patients with ischemic stroke before the age of 70 years, and 600 matched controls. Patients were classified according to the TOAST criteria.
There was no significant association between ABO phenotype (blood group O vs. non-O) and overall ischemic stroke (multivariable odds ratio of 0.9, 95% confidence interval 0.7-1.2). This was also true for blood group O vs. A and O vs. B. Furthermore, no association between ABO genotypes and ischemic stroke was detected. The ischemic stroke subtype analysis was confined to large-vessel disease, small-vessel disease, cardioembolic stroke and cryptogenic stroke. In this analysis, there was no significant association between any ischemic stroke subtype and ABO phenotype or genotype.
The findings in this study suggest that ABO phenotype or genotype does not have a major impact in the pathophysiology of ischemic stroke or any of the ischemic stroke subtypes.
ABO 血型系统由一个基因 ABO 编码。先前的研究报告称,血型非 O 型(即表型 A、B 或 AB)与心肌梗死之间存在关联。然而,关于卒中与 ABO 的研究则更为稀少。因此,我们旨在探究 ABO 表型或基因型是否与缺血性卒中和/或缺血性卒中等发病亚型相关。
该研究在萨赫勒格伦斯卡学院缺血性卒中研究(SAHLSIS)中进行,该研究纳入了 600 例年龄在 70 岁以下的缺血性卒中患者和 600 名匹配对照者。患者根据 TOAST 标准进行分类。
ABO 表型(血型 O 型与非 O 型)与总体缺血性卒中之间无显著相关性(多变量比值比为 0.9,95%置信区间为 0.7-1.2)。血型 O 型与 A 型和 O 型与 B 型之间也是如此。此外,ABO 基因型与缺血性卒中之间也未发现相关性。缺血性卒中型别分析仅限于大血管疾病、小血管疾病、心源性栓塞性卒中和隐源性卒中等。在此分析中,任何缺血性卒中型别与 ABO 表型或基因型之间均无显著相关性。
本研究结果表明,ABO 表型或基因型在缺血性卒中或任何缺血性卒中型别发病机制中无重要影响。