Blais Claudia, Germain Marc, Delage Gilles, Grégoire Yves
National Public Health Institute of Quebec, Quebec City, Canada.
Faculty of Pharmacy, Laval University, Quebec City, Canada.
Blood Transfus. 2016 Sep;14(5):455-9. doi: 10.2450/2016.0303-15. Epub 2016 Apr 28.
The association between antigens A and B and arterial thrombosis, such as coronary heart disease, cerebrovascular disease or peripheral vascular disease, is still unclear. We evaluated the association between blood groups and thrombotic events in a cohort of blood donors from the province of Quebec, Canada.
Among all whole blood donors aged ≥18 years in Quebec between June 1990 and March 2009, a study sample with known blood groups was linked with the provincial hospitalisation and death records to count vascular events. All hospital admissions and deaths with codes for primary and relevant secondary diagnoses of coronary, cerebrovascular or peripheral diseases, including coronary heart disease interventions, were included. Cox regression was used to evaluate the hazard ratio associated between blood groups and these events adjusted for other baseline characteristics.
Among the blood donors, 64,686 had a known blood group and were linked with the provincial health databases. The mean age of these donors was 38 years. The Cox multivariate adjusted hazard ratio for coronary, cerebrovascular or peripheral diseases was 1.19 (95% confidence interval: 1.01-1.40) for subjects with blood group AB compared to those with blood group O. There were no statistically significant associations with other blood groups. Only among women aged ≥40 years did those with blood group A have a higher hazard ratio for coronary heart disease (1.40 [1.01-1.92]) than those with blood group O, after adjusting for other characteristics.
When compared to blood group O, only blood group AB was associated with a higher risk of hospitalisation or death because of thrombotic events such as coronary, cerebrovascular or peripheral diseases. However, the associations differed according to age and sex because only females aged ≥40 years with blood group A had a higher risk of coronary heart disease.
抗原A和B与动脉血栓形成（如冠心病、脑血管疾病或外周血管疾病）之间的关联仍不明确。我们评估了加拿大魁北克省一群献血者的血型与血栓形成事件之间的关联。
在1990年6月至2009年3月期间魁北克省所有年龄≥18岁的全血献血者中，将已知血型的研究样本与省级住院和死亡记录相联系，以统计血管事件。纳入所有具有冠状动脉、脑血管或外周疾病的主要及相关次要诊断编码的住院和死亡病例，包括冠心病干预措施。采用Cox回归评估血型与这些事件之间的风险比，并对其他基线特征进行调整。
在献血者中，64686人有已知血型，并与省级健康数据库相联系。这些献血者的平均年龄为38岁。与O型血受试者相比，AB型血受试者发生冠状动脉、脑血管或外周疾病的Cox多变量调整风险比为1.19（95%置信区间：1.01-1.40）。与其他血型无统计学显著关联。仅在年龄≥40岁的女性中，调整其他特征后，A型血女性患冠心病的风险比高于O型血女性（1.40[1.01-1.92]）。
与O型血相比，只有AB型血与因冠状动脉、脑血管或外周疾病等血栓形成事件导致的住院或死亡风险较高有关。然而，这种关联因年龄和性别而异，因为只有年龄≥40岁的A型血女性患冠心病的风险较高。
