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Cholinergic aspects of aging and Alzheimer's disease.

作者信息

Mesulam Marsel

机构信息

Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Chicago, Illinois 60612, USA.

出版信息

Biol Psychiatry. 2012 May 1;71(9):760-1. doi: 10.1016/j.biopsych.2012.02.025.

DOI:10.1016/j.biopsych.2012.02.025
PMID:22482884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3712351/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e5a/3712351/926dd3602602/nihms486122f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e5a/3712351/926dd3602602/nihms486122f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e5a/3712351/926dd3602602/nihms486122f1.jpg

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Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA1 pyramidal cells.CA1锥体神经元中，毒蕈碱受体激活后，棘突头部丝状伪足快速且可逆的形成。
J Physiol. 2011 Sep 1;589(17):4353-64. doi: 10.1113/jphysiol.2010.204446. Epub 2011 Jul 18.
3
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
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NPJ Parkinsons Dis. 2024 Jun 29;10(1):127. doi: 10.1038/s41531-024-00743-w.
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Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed.认知老化与灵长类基底前脑再探：揭示 GABA 能神经元的不成比例易损性。
J Neurosci. 2023 Dec 6;43(49):8425-8441. doi: 10.1523/JNEUROSCI.0456-23.2023.
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New perspectives on the basal forebrain cholinergic system in Alzheimer's disease.阿尔茨海默病基底前脑胆碱能系统的新观点。
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Alterations of sleep oscillations in Alzheimer's disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus.阿尔茨海默病睡眠振荡的改变：皮层、海马体和丘脑 GABA 能神经元的潜在作用。
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5
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6
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7
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8
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9
Age-related shrinkage of cortically projecting cholinergic neurons: a selective effect.与年龄相关的皮质投射胆碱能神经元萎缩：一种选择性效应。
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