Dahle Kevin W, Sontheimer Richard D
Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Dermatol Online J. 2012 Mar 15;18(3):6.
Nasal vestibular furunculosis is a mucocutaneous disorder commonly seen in the general population. Despite its prevalence in clinical practice, it has been inconsistently described and labeled in the medical literature. We present a case of nasal vestibular furunculosis presenting as recurrent exquisitely tender unilateral erythema and edema of the nasal tip (i.e., the Rudolph sign--as in Rudolph The Red Nosed Reindeer). This symptom complex responded rapidly to topical intranasal mupirocin ointment treatment after having previously failed other treatments including a topical intranasal triple antibiotic ointment and oral doxycycline. This case is instructive as it describes a heretofore under-recognized, but not uncommon, mucocutaneous clinical entity that has been linked to more serious head and neck infections and likely has relevance to the intranasal carriage of Staphylococcus aureus. We review the limited published literature on this mucocutaneous disorder including its nosology and propose future lines of investigation for better defining its clinical significance and pathogenesis.
鼻前庭疖肿是一种在普通人群中常见的黏膜皮肤疾病。尽管其在临床实践中较为普遍，但在医学文献中的描述和命名并不一致。我们报告一例鼻前庭疖肿病例，表现为鼻尖反复出现极其疼痛的单侧红斑和水肿（即鲁道夫征——如同红鼻子驯鹿鲁道夫）。在先前包括局部鼻内三联抗生素软膏和口服多西环素等其他治疗均失败后，该症状复合体对局部鼻内莫匹罗星软膏治疗反应迅速。该病例具有指导意义，因为它描述了一种此前未被充分认识但并不罕见的黏膜皮肤临床实体，该实体与更严重的头颈部感染有关，并且可能与金黄色葡萄球菌的鼻内携带有关。我们回顾了关于这种黏膜皮肤疾病的有限已发表文献，包括其分类学，并提出了未来的研究方向，以更好地界定其临床意义和发病机制。
