含 1,3,4-噻二唑的苯并硒唑啉酮衍生物的合成及抗肿瘤活性评价。
Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives.
机构信息
Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China.
出版信息
Bioorg Med Chem Lett. 2012 May 1;22(9):3191-3. doi: 10.1016/j.bmcl.2012.03.043. Epub 2012 Mar 21.
A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research.
一系列新型含 1,3,4-噻二唑的苯并硒唑酮衍生物通过 2-氯硒苯甲酰氯和 2-氨基-5-取代-1,3,4-噻二唑缩合制备。在 SSMC-7721、MCF-7 和 A-549 细胞中评估了它们的体外抗增殖活性。结果表明，在不同的肿瘤细胞中，一些化合物具有良好的抗增殖活性、一定的选择性和进一步研究的潜在价值。
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