喹啉基和菲啶基乙酰胺作为缓激肽 B1 受体拮抗剂。
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.
机构信息
Gedeon Richter Plc., Budapest 10. POB 27, H-1475, Hungary.
出版信息
Bioorg Med Chem Lett. 2012 May 1;22(9):3095-9. doi: 10.1016/j.bmcl.2012.03.065. Epub 2012 Mar 21.
PMID:22483585
Abstract
A new series of quinolinyl- and phenantridinyl-acetamides were synthesizer and evaluated against bradykinin B1 receptor. In vitro metabolic stability data were reported for the key compounds.The analgesic effect of compound 20 from the phenantridine series was proved in-vivo.
摘要
一系列新的喹啉基和菲啶基乙酰胺被合成，并对缓激肽 B1 受体进行了评估。报告了关键化合物的体外代谢稳定性数据。从菲啶系列中得到的化合物 20 的体内镇痛效果得到了证实。
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