在有心肌梗死病史的突尼斯患者中，因子 V Leiden 和凝血酶原 G20210A 多态性之间缺乏关联。
Lack of association between factor V Leiden and prothrombin G20210A polymorphisms in Tunisian subjects with a history of myocardial infarction.
机构信息
Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunis, Tunis, Tunisia.
出版信息
Cardiovasc Pathol. 2013 Jan-Feb;22(1):39-41. doi: 10.1016/j.carpath.2012.03.002. Epub 2012 Apr 5.
BACKGROUND
Myocardial infarction is a multifactorial disease. It is provoked by occlusions in the coronary arteries resulting from exposure to multiple risk factors.
OBJECTIVE
To study the risk of myocardial infarction associated with the gene polymorphisms of factor V Leiden and factor II (G20210A).
MATERIALS AND METHODS
Cases consisted of 100 myocardial infarction patients who were hospitalized in the Principal Military Hospital of Tunis and 200 control subjects with no history of myocardial infarction.
RESULTS
The prevalence of the factor V Leiden was higher in myocardial infarction patients (9%) than in control subjects (6%) with an OR=1.55 (95% CI=0.58-4.12), whereas the prevalence of prothrombin G20210A mutation was 3% and 2.5% in the patient and control groups, respectively [OR=1.21 (95% CI=0.22-5.94)].
CONCLUSION
Our results indicate that neither factor V Leiden nor the prothrombin G20210A contributed to the risk factors for myocardial infarction.
背景
心肌梗死是一种多因素疾病。它是由冠状动脉暴露于多种危险因素引起的阻塞引起的。
目的
研究因子 V 莱顿和因子 II（G20210A）基因多态性与心肌梗死风险的关系。
材料和方法
病例组由 100 名在突尼斯主要军事医院住院的心肌梗死患者和 200 名无心肌梗死病史的对照组组成。
结果
因子 V 莱顿在心肌梗死患者（9%）中的发生率高于对照组（6%），OR=1.55（95%CI=0.58-4.12），而凝血酶原 G20210A 突变在患者和对照组中的发生率分别为 3%和 2.5%[OR=1.21（95%CI=0.22-5.94）]。
结论
我们的结果表明，因子 V 莱顿和凝血酶原 G20210A 均不能增加心肌梗死的危险因素。
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