Division of Cardiology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy.
J Cardiovasc Med (Hagerstown). 2010 Feb;11(2):125-6. doi: 10.2459/JCM.0b013e32832f5d1b.
We report a case of myocardial infarction at a young age in a person with a medical history of repeated thrombophlebitis, who was heterozygous for the prothrombin G20210A mutation and homozygous for factor V Leiden mutation. A coronary angiography revealed the presence of a moderate atherosclerotic plaque (60%) in the left anterior descending coronary artery, which gave rise to suspicion of a relationship between prothrombotic gene mutations and atherosclerosis. Genetic screening for inherited thrombophilia, especially in the presence of a strong familiarity or previous venous thrombosis, and the evaluation of atherosclerotic risk factors, may be critical information for primary prevention of arterial thrombosis.
我们报告了一例年轻患者发生心肌梗死的病例，该患者有反复发作性血栓性静脉炎病史，为凝血酶原 G20210A 突变杂合子和因子 V 莱顿突变纯合子。冠状动脉造影显示左前降支存在中度粥样硬化斑块（60%），这引起了对血栓形成基因突变与动脉粥样硬化之间关系的怀疑。遗传性血栓形成倾向的遗传筛查，特别是在存在强烈家族史或先前静脉血栓形成的情况下，以及动脉粥样硬化危险因素的评估，可能是动脉血栓形成一级预防的关键信息。
