Núcleo de Química Aplicada, Universidade Federal de Pelotas - UFPel, Campus Universitário, s/n°, 96010-900 Pelotas, RS, Brazil.
Ultrason Sonochem. 2012 Nov;19(6):1127-31. doi: 10.1016/j.ultsonch.2012.03.004. Epub 2012 Mar 21.
The efficient multicomponent synthesis of thiazolidinones from the reaction of arenealdehydes, mercaptoacetic acid and 2-picolilamine or 2-aminopyridine under ultrasound irradiation are reported. The reaction with 2-aminopyridine needs a Lewis acid catalysis to afford the corresponding 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones. All novel compounds were identified and characterized by (1)H and (13)C NMR spectra. Applying the sonochemical methodology, two series of heterocyclic thiazolidinones were synthesized in good yields after short reaction times.
超声辐射条件下，通过芳醛、巯基乙酸和 2-吡啶基乙胺或 2-氨基吡啶的反应，高效合成了噻唑烷酮。与 2-氨基吡啶的反应需要路易斯酸催化，以得到相应的 2-芳基-3-(吡啶-2-基)-1,3-噻唑烷-4-酮。所有新化合物均通过 (1)H 和 (13)C NMR 谱进行了鉴定和表征。采用超声化学方法，在较短的反应时间内，以高产率得到了两类杂环噻唑烷酮。
