Ramdani Benyounès, Zamd Mohamed, Hachim Khadija, Soulami Kenza, Ezzahidy Madiha, Souiri Malika, Fadili Wafaa, Lahboub Assia, Hanafi Leila, Boujida Meryem, Squalli Saida, Benkirane Amal, Benghanem Mohamed Gharbi, Medkouri Ghizlane
Service de Néphrologie Hémodialyse, Centre Hospitalier Ibn-Rochd, Casablanca, Maroc.
Nephrol Ther. 2012 Jul;8(4):247-58. doi: 10.1016/j.nephro.2011.11.011. Epub 2012 Apr 6.
Acute postinfectious glomerulonephritis are defined by an acute nonsuppurative inflammatory insult predominantly glomerular. Its current incidence is uncertain because of the frequency of subclinical forms. The most common infectious agent involved is beta hemolytic streptococcus group A. Acute postinfectious glomerulonephritis is uncommon in adults, and its incidence is progressively declining in developed countries. Humoral immunity plays a key role in the pathogenesis of kidney damage. Complement activation by the alternative pathway is the dominant mechanism, but a third way (lectin pathway) has been recently identified. The classic clinical presentation is sudden onset of acute nephritic syndrome after a free interval from a streptococcal infection. Treatment is essentially symptomatic and prevention is possible through improved hygiene and early treatment of infections.
急性感染后肾小球肾炎的定义为主要累及肾小球的急性非化脓性炎性损伤。由于亚临床形式的发生率，其目前的发病率尚不确定。最常见的感染病原体是A组β溶血性链球菌。急性感染后肾小球肾炎在成人中并不常见，在发达国家其发病率正在逐渐下降。体液免疫在肾损伤的发病机制中起关键作用。替代途径激活补体是主要机制，但最近发现了第三种途径（凝集素途径）。典型的临床表现是在链球菌感染的一段无症期后突然出现急性肾炎综合征。治疗主要是对症治疗，通过改善卫生条件和早期治疗感染可以预防。
