Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Research Center for Nanobiology and Nanomedicine (MOE 985 Innovative Platform), State Key Laboratory of Virology, and Wuhan Institute of Biotechnology, Wuhan University, Wuhan 430072, PR China.
Biomaterials. 2012 Jul;33(20):5130-5. doi: 10.1016/j.biomaterials.2012.03.059. Epub 2012 Apr 7.
A one-step method for synthesizing water-soluble Ag(2)S quantum dots terminated with carboxylic acid group has been reported. The crystal structure and surface of the prepared Ag(2)S quantum dots were characterized. The prepared Ag(2)S quantum dots exhibited bright photoluminescence and excellent photostabilities. The photoluminescence emissions could be tuned from visible region to near-infrared (NIR) region (from 510 nm to 1221 nm). Ultra-small sized Ag(2)S nanoclusters were synthesized with high initial monomer concentration in the current system. The in vivo imaging experiments of nude mice showed that the NIR photoluminescence of the prepared Ag(2)S quantum dots could penetrate the body of mice. Compared to the conventional NIR quantum dots, the Ag(2)S quantum dots don't contain toxic elements to body (such as Cd and Pb), thus, the prepared Ag(2)S quantum dots could serve as excellent NIR optical imaging probes and would open the opportunity to study nanodiagnostics and imaging in vivo.
已报道了一种一步法合成带羧基的水溶性 Ag(2)S 量子点的方法。对所制备的 Ag(2)S 量子点的晶体结构和表面进行了表征。所制备的 Ag(2)S 量子点具有明亮的光致发光和优异的光稳定性。光致发光发射可以从可见光区调谐到近红外（NIR）区（从 510nm 到 1221nm）。在当前体系中，采用高初始单体浓度合成了超小尺寸的 Ag(2)S 纳米团簇。裸鼠体内成像实验表明，所制备的 Ag(2)S 量子点的近红外光致发光能够穿透小鼠的身体。与传统的近红外量子点相比，Ag(2)S 量子点不含对人体有毒的元素（如 Cd 和 Pb），因此，所制备的 Ag(2)S 量子点可用作优异的近红外光学成像探针，并为体内纳米诊断和成像研究开辟机会。
