World Class University Program of Chemical Convergence for Energy & Environment (C(2)E(2)), School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangro, Gwanak-gu, Seoul 151-742, Republic of Korea.
Biomaterials. 2012 Jul;33(20):5056-66. doi: 10.1016/j.biomaterials.2012.03.064. Epub 2012 Apr 6.
Carbon sponge, an adsorbent with spatially controlled structure is demonstrated for targeting internalized radiocesium and other radionuclides in human body. Three dimensionally ordered macroporous (3DOM) carbons derived from inverse opal replicas of colloidal-crystal template exhibit large surface area and high porosity, resulting in highly efficient adsorbents for radionuclides. It is also possible to enhance binding affinity and selectivity to radionuclide targets by decoration of 3DOM carbon surfaces with Prussian blue (PB) nanoparticles, and synthesized PB nanoparticles reveal low toxicity toward macrophage cells with potential advantages over oral administration. It is noteworthy that the maximum (133)Cs adsorption capacity of PB-decorated 3DOM carbons is 40.07 mmol g(-1) which is ca. 30 and 200 times higher than that of commercialized medicine Radiogardase(®) and bulk PB, respectively. Further, adsorption kinetics study indicates that the PB-decorated 3DOM carbons have the homogenous surface for (133)Cs ion adsorption and all sites have equal adsorption energies in terms of ion exchange between the cyano groups of the PB-decorated 3DOM carbons and radionuclides. As a concept of the oral-administrable "carbon sponge", the PB-decorated 3DOM carbons offer useful implications in the separation science of radioactive materials and important insight for designing novel materials for treatment of patients or suspected internal contamination with radioactive materials.
碳海绵是一种具有空间控制结构的吸附剂，可用于靶向人体内的内摄放射性铯和其他放射性核素。由胶体晶体模板的反蛋白石复制品衍生的三维有序大孔（3DOM）碳具有大的表面积和高孔隙率，是放射性核素的高效吸附剂。通过用普鲁士蓝（PB）纳米粒子修饰 3DOM 碳表面，也可以提高与放射性核素靶标的结合亲和力和选择性，并且合成的 PB 纳米粒子对巨噬细胞表现出低毒性，与口服给药相比具有潜在优势。值得注意的是，PB 修饰的 3DOM 碳的最大（133）Cs 吸附容量为 40.07 mmol g(-1)，分别约为商业化药物 Radiogardase(®)和块状 PB 的 30 和 200 倍。此外，吸附动力学研究表明，PB 修饰的 3DOM 碳具有（133）Cs 离子吸附的均匀表面，并且根据 PB 修饰的 3DOM 碳的氰基基团与放射性核素之间的离子交换，所有位点都具有相等的吸附能。作为可口服的“碳海绵”的概念，PB 修饰的 3DOM 碳在放射性材料的分离科学中具有有用的意义，并为设计用于治疗放射性材料污染的患者或疑似内部污染的新型材料提供了重要的见解。
