Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin), Institute for Technology Research and Innovation, Deakin University, VIC 3217, Australia.
Drug Discov Today. 2012 Jul;17(13-14):774-83. doi: 10.1016/j.drudis.2012.03.007. Epub 2012 Mar 30.
Ribosome-inactivating proteins (RIPs) are mainly present in plants and function to inhibit protein synthesis through the removal of adenine residues from eukaryotic ribosomal RNA (rRNA). They are broadly classified into two groups: type I and type II. Type I RIPs are a diverse family of proteins comprising a single polypeptide chain, whereas type II RIPs are heterodimeric glycoproteins comprising an A-chain (functionally equivalent to a type I RIP) linked via a disulphide bond to a B chain, mediating cell entry. In this review, we describe common type I and type II RIPs, their diverse biological functions, mechanism of cell entry, stability in plasma and antigenicity. We end with a discussion of promising applications for RIPs in biomedicine.
核糖体失活蛋白（RIPs）主要存在于植物中，通过从真核核糖体 RNA（rRNA）中去除腺嘌呤残基来抑制蛋白质合成。它们广泛分为两类：I 型和 II 型。I 型 RIP 是由单一多肽链组成的多种蛋白家族，而 II 型 RIP 是由 A 链（在功能上等同于 I 型 RIP）通过二硫键与 B 链连接的异二聚体糖蛋白，介导细胞进入。在这篇综述中，我们描述了常见的 I 型和 II 型 RIPs 及其多种生物学功能、细胞进入机制、在血浆中的稳定性和抗原性。最后，我们讨论了 RIP 在生物医学中的有前途的应用。
