Centre Pluridisciplinaire d'Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Clin Transl Oncol. 2012 Apr;14(4):243-53. doi: 10.1007/s12094-012-0792-4.
Malignant mixed Müllerian tumours (malignant mixed mesodermal tumours, MMMT) of the uterus are metaplastic carcinomas with a sarcomatous component and thus they are also called carcinosarcomas. It has now been accepted that the sarcomatous component is derived from epithelial elements that have undergone metaplasia. The process that produces this metaplasia is epithelial to mesenchymal transition (EMT), which has recently been described as a neoplasia-associated programme shared with embryonic development and enabling neoplastic cells to move and metastasise. The ubiquitin proteasome system (UPS) regulates the turnover and functions of hundreds of cellular proteins. It plays important roles in EMT by being involved in the regulation of several pathways participating in the execution of this metastasis-associated programme. In this review the specifi c role of UPS in EMT of MMMT is discussed and therapeutic opportunities from UPS manipulations are proposed.
子宫恶性混合 Müllerian 肿瘤（恶性混合中胚层肿瘤，MMMT）是一种具有肉瘤成分的间变性癌，因此也被称为癌肉瘤。现在已经公认，肉瘤成分来源于经历了化生的上皮细胞。产生这种化生的过程是上皮细胞向间充质转化（EMT），最近它被描述为一种与肿瘤发生相关的程序，与胚胎发育共享，并使肿瘤细胞能够迁移和转移。泛素蛋白酶体系统（UPS）调节数百种细胞蛋白的周转和功能。它通过参与调节参与执行这种与转移相关程序的几个途径，在 EMT 中发挥重要作用。在这篇综述中，讨论了 UPS 在 MMMT 的 EMT 中的特定作用，并提出了 UPS 操作的治疗机会。
