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手部皮肤和滑膜环斑拟青霉感染的罕见病例经伏立康唑治疗成功,并复习文献。

Unusual case of cutaneous and synovial Paecilomyces lilacinus infection of hand successfully treated with voriconazole and review of published literature.

机构信息

Department of Internal Medicine, Union Memorial Hospital, Baltimore, MD 21218, USA.

出版信息

Mycopathologia. 2012 Sep;174(3):255-8. doi: 10.1007/s11046-012-9540-0. Epub 2012 Apr 8.

Abstract

Paecilomyces lilacinus infection is rare and is found worldwide. The majority of infections occur in immunocompromised people. Among immunocompetent patients, cutaneous infections are the second most common site of infection but are difficult to treat because of antifungal resistance. We report a case of hand cutaneous involvement with synovitis in an immunocompetent patient that improved after treatment with oral voriconazole. To the best of our knowledge, there are only five published cases of cutaneous P.lilacinus infection, all in immunocompromised patient, treated with oral voriconazole. We review all previously reported cases.

摘要

棘白菌素属感染较为罕见,全球均有发现。大多数感染发生于免疫功能低下人群。在免疫功能正常的患者中,皮肤感染是第二常见的感染部位,但由于抗真菌药物耐药性,治疗较为困难。我们报告了一例免疫功能正常患者手部皮肤受累伴滑膜炎,经口服伏立康唑治疗后病情改善。据我们所知,仅有 5 例已发表的皮肤棘白菌素属感染病例,均发生于免疫功能低下患者,采用口服伏立康唑治疗。我们对所有先前报道的病例进行了回顾。

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