Mori Yuki, Fukuoka Mayuko, Inagaki Mizuho, Iwamoto Satoshi, Yabe Tomio, Kanamaru Yoshihiro
United Graduate School of Agricultural Science, Gifu University, Gifu, Japan.
Biosci Biotechnol Biochem. 2012;76(4):843-6. doi: 10.1271/bbb.110896. Epub 2012 Apr 7.
Native alpha-lactalbumins (α-LA) from equine, bovine, and human milk were not cytotoxic. However, after treatment with trifluoroethanol (TFE), all three α-LAs exhibited cytotoxicity. Toxic potencies were distinctly different among them. Equine α-LA was the most robust, bovine α-LA was moderate, and human α-LA was weak. There were no significant structural changes as between the native and the TFE-treated α-LAs.
来自马奶、牛奶和人乳的天然α-乳白蛋白（α-LA）没有细胞毒性。然而，用三氟乙醇（TFE）处理后，所有三种α-LA都表现出细胞毒性。它们之间的毒性强度明显不同。马α-LA的毒性最强，牛α-LA中等，人α-LA较弱。天然α-LA和经TFE处理的α-LA之间没有明显的结构变化。
