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Optimizing infliximab therapy for inflammatory bowel disease- the tools are getting sharper.

作者信息

Dubeau Marie-France, Ghosh Subrata

机构信息

Inflammatory Bowel Disease Clinic Alberta IBD Consortium Gastroenterology Division, Department of Medicine University of Calgary Calgary, Alberta.

出版信息

Gastroenterol Hepatol (N Y). 2012 Feb;8(2):134-6.

PMID:22485083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3317513/
Abstract
摘要

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本文引用的文献

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Trough levels and antibodies to infliximab may not predict response to intensification of infliximab therapy in patients with inflammatory bowel disease.英夫利昔单抗的 trough 水平和抗体可能无法预测炎症性肠病患者强化英夫利昔单抗治疗的反应。
Inflamm Bowel Dis. 2012 Jul;18(7):1199-206. doi: 10.1002/ibd.21839. Epub 2011 Aug 29.
2
Clinical utility of antihuman lambda chain-based enzyme-linked immunosorbent assay (ELISA) versus double antigen ELISA for the detection of anti-infliximab antibodies.基于抗人λ链的酶联免疫吸附试验（ELISA）与双抗原 ELISA 检测抗英夫利昔单抗抗体的临床实用性比较。
Inflamm Bowel Dis. 2012 Sep;18(9):1628-33. doi: 10.1002/ibd.21919. Epub 2011 Oct 29.
3
A Crohn's disease patient who does not respond to infliximab: what is next?一位对英夫利昔单抗无反应的克罗恩病患者：接下来该怎么办？
Clin Gastroenterol Hepatol. 2011 Dec;9(12):1033-8. doi: 10.1016/j.cgh.2011.05.027. Epub 2011 Jun 6.
4
Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease.英夫利昔单抗谷浓度及抗英夫利昔单抗抗体在克罗恩病中的临界值水平与诊断准确性
Scand J Gastroenterol. 2011 Mar;46(3):310-8. doi: 10.3109/00365521.2010.536254. Epub 2010 Nov 18.
5
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?世界胃肠病学大会与欧洲克罗恩病和结肠炎组织关于 IBD 的生物治疗的伦敦立场声明：何时开始，何时停止，选择哪种药物，以及如何预测应答？
Am J Gastroenterol. 2011 Feb;106(2):199-212; quiz 213. doi: 10.1038/ajg.2010.392. Epub 2010 Nov 2.
6
The immunogenic part of infliximab is the F(ab')2, but measuring antibodies to the intact infliximab molecule is more clinically useful.英夫利昔单抗的免疫原性部分是 F(ab')2，但检测完整英夫利昔单抗分子的抗体在临床上更有用。
Gut. 2011 Jan;60(1):41-8. doi: 10.1136/gut.2009.201533. Epub 2010 Jun 2.
7
Serum albumin concentration: a predictive factor of infliximab pharmacokinetics and clinical response in patients with ulcerative colitis.血清白蛋白浓度：溃疡性结肠炎患者英夫利昔单抗药代动力学及临床反应的预测因素
Int J Clin Pharmacol Ther. 2010 May;48(5):297-308. doi: 10.5414/cpp48297.
8
Infliximab, azathioprine, or combination therapy for Crohn's disease.英夫利昔单抗、硫唑嘌呤或联合治疗克罗恩病。
N Engl J Med. 2010 Apr 15;362(15):1383-95. doi: 10.1056/NEJMoa0904492.
9
Clinical utility of measuring infliximab and human anti-chimeric antibody concentrations in patients with inflammatory bowel disease.在炎症性肠病患者中测量英夫利昔单抗和人抗嵌合抗体浓度的临床实用性。
Am J Gastroenterol. 2010 May;105(5):1133-9. doi: 10.1038/ajg.2010.9. Epub 2010 Feb 9.
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Gut. 2010 Jan;59(1):49-54. doi: 10.1136/gut.2009.183095.