β-环糊精某些衍生物的生物活性
Biological activity of some derivatives of β-cyclodextrin.
作者信息
Batalova T A, Dorovskich V A, Kurochkina G I, Grachev M K, Plastinin M L, Sergievich A A
机构信息
Amur State Medical Academy, Blagoveshchensk, Russia.
出版信息
Bull Exp Biol Med. 2011 Oct;151(6):698-701. doi: 10.1007/s10517-011-1419-4.
New compounds of β-cyclodextrin containing covalently bound (conjugated) residues of acetylsalicylic and 1-(4-isobutylphenyl)-propionic acids were synthesized in the reaction of chlorides of the corresponding acids with β-cyclodextrin. We studied antiplatelet and antiphlogistic properties of these substances. It was shown that new compounds are comparable and in some cases are superior to the reference drugs acetylsalicylic acid and ibuprofen by anti-inflammatory and antiaggregant activities.
通过相应酸的氯化物与β-环糊精反应，合成了含有共价结合（共轭）乙酰水杨酸和1-(4-异丁基苯基)丙酸残基的新型β-环糊精化合物。我们研究了这些物质的抗血小板和抗炎特性。结果表明，这些新化合物在抗炎和抗聚集活性方面与参考药物乙酰水杨酸和布洛芬相当，在某些情况下甚至更优。
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