Gazdíková K, Gazdík F, Kajaba I, Hučková D, Okruhlica L, Farkašová D
Fakulta Asetrovatel'stva a Zdravotníckych Stúdií Slovenskej Univerzity, Slovenská Republika, Rektorka Dr. h. c. prof. PhDr. Dana Farkašová, CSc.
Vnitr Lek. 2012 Mar;58(3):179-82.
Virus of hepatitis C (HCV) is the leading cause of chronic liver disease, including cirrhosis and cancer, and the most common indication for liver transplantation. In industrialised countries, injecting drug use is currently the most important risk factor for infection with hepatitis C, resulting in high prevalence of hepatitis C among injecting drug users (IDUs). The aim of the study was to assess the seroprevalence of HCV infection and distribution of genotypes among IDUs in the years 2004-2008.
A total number of 846 probands, both sexes (590 males and 256 females) with mean age from 24 to 29 years were investigated in the years 2004-2008. Standard virological tests were performed.
The seroprevalence of anti-HCV positivity during the years 2004-2008 were in range 34-78% and positivity of HCV RNA assessed by PCR method were in range 17-71%. The genotypes distribution was in favour of genotype 3.
In Slovakia IDUs represent risk group with high prevalence of hepatitis C. These results are comparable to those published in other European countries.
丙型肝炎病毒（HCV）是导致慢性肝病（包括肝硬化和癌症）的主要原因，也是肝移植最常见的指征。在工业化国家，注射吸毒是目前丙型肝炎感染最重要的危险因素，导致注射吸毒者（IDU）中丙型肝炎的高患病率。本研究的目的是评估2004 - 2008年期间注射吸毒者中HCV感染的血清流行率和基因型分布。
2004 - 2008年期间共调查了846名先证者，男女皆有（590名男性和256名女性），平均年龄在24至29岁之间。进行了标准的病毒学检测。
2004 - 2008年期间抗-HCV阳性的血清流行率在34%至78%之间，通过PCR方法评估的HCV RNA阳性率在17%至71%之间。基因型分布以3型为主。
在斯洛伐克，注射吸毒者是丙型肝炎高患病率的危险人群。这些结果与其他欧洲国家发表的结果相当。
