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[肾病患者的氧化应激]

[Oxidative stress in kidney disease patients].

作者信息

Vostálová J, Galandáková A, Strebl P, Zadražil J, Kajabová M, Schneiderka P

机构信息

ústav Lékarské Chemie a Biochemie Lékarské Fakulty UP Olomouc, Prednostka prof. RNDr. Jitka Ulrichová, CSc.

出版信息

Vnitr Lek. 2012 Mar;58(3):202-7.

Abstract

Patients with chronic kidney disease are exposed to oxidative stress (OS) that contributes to deterioration of health. Decrease in renal excretory capacity contributes to the accumulation of pro-oxidative substances that are detrimental not only to kidney but to the whole organism including the cardiovascular system. Components of antioxidant system play an important role in the elimination of the OS. The monitoring of antioxidant levels and products of oxidative damage in these patients and the correct interpretation of relationship between these markers and the function of kidney and other organs may contribute to the more effective treatment and health improvement of the patients.

摘要

慢性肾脏病患者面临氧化应激(OS),这会导致健康状况恶化。肾脏排泄能力的下降会导致促氧化物质的积累,这些物质不仅对肾脏有害,而且对包括心血管系统在内的整个机体都有害。抗氧化系统的组成部分在消除氧化应激方面发挥着重要作用。监测这些患者的抗氧化水平和氧化损伤产物,以及正确解读这些标志物与肾脏和其他器官功能之间的关系,可能有助于更有效地治疗患者并改善其健康状况。

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