Lovelace Respiratory Research Institute , Albuquerque, NM 87108, USA.
Inhal Toxicol. 2012 Apr;24(5):310-9. doi: 10.3109/08958378.2012.661800.
Exposure atmospheres for rodent inhalation toxicology studies were generated to enable the evaluation of biological responses to a simulated downwind coal combustion atmosphere. A composition representing a single test case of emissions components as they may exist tens to hundreds of miles from a coal-fired power plant was developed. The particulate matter (PM) was 99% sulfate (partially neutralized) and 1% ash. Sulfate was present in equimolar concentrations to sulfur dioxide (SO₂). Gaseous nitrogen species included nitrogen monoxide (NO), nitrogen dioxide (NO₂), and nitric acid (HNO₃). At the high-exposure level, the gaseous species target concentrations were 0.2 ppm SO₂, 0.6 ppm NO, 0.3 ppm NO₂, and 0.1 ppm HNO₃. The test atmosphere was produced by combining effluent from a laboratory coal combustor with sulfate generated through an evaporation-condensation generator. These atmospheres were used to conduct inhalation toxicology studies that have been previously reported.
为了评估模拟下风燃煤燃烧环境对生物的反应，生成了啮齿动物吸入毒理学研究的暴露环境。开发了一种代表从燃煤电厂数十到数百英里处排放成分的单一测试情况的组成。颗粒物（PM）为 99%的硫酸盐（部分中和）和 1%的灰分。硫酸盐与二氧化硫（SO₂）的浓度相等。气态氮物种包括一氧化氮（NO）、二氧化氮（NO₂）和硝酸（HNO₃）。在高暴露水平下，气态物质的目标浓度为 0.2 ppm SO₂、0.6 ppm NO、0.3 ppm NO₂和 0.1 ppm HNO₃。测试气氛是通过将实验室燃煤炉的废气与通过蒸发-冷凝发生器产生的硫酸盐混合而成。这些环境被用于进行先前报道的吸入毒理学研究。
