Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China.
Retina. 2012 Oct;32(9):1838-43. doi: 10.1097/IAE.0b013e31824fd384.
To compare the profiles of elevated intraocular pressure (IOP) after anterior and posterior subtenon injections (PSTIs) of triamcinolone.
In this retrospective case series, 131 patients (131 eyes) with a single anterior subtenon injection (ASTI) of triamcinolone acetonide acetate (20 mg in 0.5 mL) and 49 patients (49 eyes) with a single PSTI of triamcinolone acetonide acetate (40 mg in 0.4 mL) were studied for changes in IOP. Changes in IOP compared with the baseline and fellow eyes were analyzed for both the ASTI and PSTI groups.
The study revealed that ASTI was 2.4 times more likely (95% confidence interval, 1.02-5.9) to have an IOP elevation >21 mmHg when compared with the PSTI (P = 0.0389). Twenty-one percent (28 of 131) of eyes having an IOP >21 mmHg were found in the ASTI group, while only 12% (6 of 49) were found in the PSTI group. Similarly, ASTI was 5.3 times more likely (95% confidence interval, 1.2-22.5) to have an IOP >30 mmHg compared with the PSTI (P = 0.03, one-tailed). Anterior subtenon injection had 7% (9 of 131) of eyes with IOP >30 mmHg, while only 2% (1 of 49) were present in the PSTI group. Age was negatively associated with IOP elevation (P < 0.05), and the baseline IOP was positively associated with IOP elevation (P < 0.05). The mean IOP elevation from the baseline was also found to be greater in ASTI (3.1 mmHg) than in PSTI (1.8 mmHg; P = 0.02, generalized estimating equation).
An ASTI of triamcinolone acetonide may bear a higher risk of developing elevated IOP than a PSTI of triamcinolone acetonide.
比较曲安奈德前、后巩膜下注射（PSTI）后眼压升高的特点。
本回顾性病例系列研究纳入了 131 例（131 只眼）接受单眼曲安奈德乙酰丁酯前巩膜下注射（ASTI；20mg 溶于 0.5mL）和 49 例（49 只眼）接受单眼 PSTI 的患者，观察眼压变化。分析 ASTI 和 PSTI 组患者的眼压与基线眼压及对侧眼眼压的变化。
研究发现，ASTI 导致眼压升高>21mmHg 的可能性是 PSTI 的 2.4 倍（95%置信区间，1.02-5.9；P=0.0389）。ASTI 组有 21%（28 只眼）眼压>21mmHg，而 PSTI 组仅有 12%（6 只眼）。同样，ASTI 导致眼压升高>30mmHg 的可能性是 PSTI 的 5.3 倍（95%置信区间，1.2-22.5；P=0.03，单侧检验）。ASTI 组有 7%（9 只眼）眼压>30mmHg，而 PSTI 组仅有 2%（1 只眼）。年龄与眼压升高呈负相关（P<0.05），基线眼压与眼压升高呈正相关（P<0.05）。ASTI 组的平均眼压升高幅度（3.1mmHg）也大于 PSTI 组（1.8mmHg；P=0.02，广义估计方程）。
与 PSTI 相比，ASTI 可能会增加曲安奈德乙酰丁酯注射后眼压升高的风险。
