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微创肌切开术治疗食管贲门失弛缓症:手术方法的演变及治疗算法

Minimally invasive myotomy for the treatment of esophageal achalasia: evolution of the surgical procedure and the therapeutic algorithm.

作者信息

Bresadola Vittorio, Feo Carlo V

机构信息

General Surgery and Transplantation, University Hospital of Udine, Udine, Italy.

出版信息

Surg Laparosc Endosc Percutan Tech. 2012 Apr;22(2):83-7. doi: 10.1097/SLE.0b013e318243368f.

Abstract

Achalasia is a rare disease of the esophagus, characterized by the absence of peristalsis in the esophageal body and incomplete relaxation of the lower esophageal sphincter, which may be hypertensive. The cause of this disease is unknown; therefore, the aim of the therapy is to improve esophageal emptying by eliminating the outflow resistance caused by the lower esophageal sphincter. This goal can be accomplished either by pneumatic dilatation or surgical myotomy, which are the only long-term effective therapies for achalasia. Historically, pneumatic dilatation was preferred over surgical myotomy because of the morbidity associated with a thoracotomy or a laparotomy. However, with the development of minimally invasive techniques, the surgical approach has gained widespread acceptance among patients and gastroenterologists and, consequently, the role of surgery has changed. The aim of this study was to review the changes occurred in the surgical treatment of achalasia over the last 2 decades; specifically, the development of minimally invasive techniques with the evolution from a thoracoscopic approach without an antireflux procedure to a laparoscopic myotomy with a partial fundoplication, the changes in the length of the myotomy, and the modification of the therapeutic algorithm.

摘要

贲门失弛缓症是一种罕见的食管疾病,其特征为食管体部无蠕动以及食管下括约肌不完全松弛,后者可能处于高压状态。本病病因不明;因此,治疗目的是通过消除食管下括约肌引起的流出道阻力来改善食管排空。这一目标可通过气囊扩张术或手术肌切开术实现,这两种方法是治疗贲门失弛缓症仅有的长期有效疗法。从历史上看,由于开胸手术或剖腹手术相关的发病率,气囊扩张术比手术肌切开术更受青睐。然而,随着微创技术的发展,手术方法已在患者和胃肠病学家中得到广泛认可,因此,手术的作用发生了变化。本研究的目的是回顾过去20年贲门失弛缓症手术治疗中发生的变化;具体而言,是微创技术的发展,从无抗反流程序的胸腔镜手术演变为行部分胃底折叠术的腹腔镜肌切开术、肌切开长度的变化以及治疗算法的修改。

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