Lee Stella, Kundaria Summit, Ferguson Berrylin J
Division of Sinonasal Disorders and Allergy, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Curr Opin Otolaryngol Head Neck Surg. 2012 Jun;20(3):179-87. doi: 10.1097/MOO.0b013e328352b839.
Allergic rhinitis often coexists with chronic rhinosinusitis (CRS). The purpose of this review is to provide a practical algorithm for the treatment of patients with allergic rhinitis and CRS.
Despite conflicting literature on the causative association of allergic rhinitis with CRS, recent research shows a higher incidence of allergic rhinitis in CRS patients refractory to medical therapy. Local IgE is hypothesized to play a role in the inflammation characteristic of both disorders, even in patients who test negative for inhalant allergies.
As allergic rhinitis and CRS symptoms overlap, medications appropriate for one disorder may also be appropriate for the other. The exception would be allergen immunotherapy in the absence of allergy and antibiotics in the absence of infection. Given these principles, we have developed and provide a personalized management strategy for patients with symptoms of allergic rhinitis and CRS based on the individual's response to therapy.
变应性鼻炎常与慢性鼻-鼻窦炎(CRS)共存。本综述旨在提供一种针对变应性鼻炎合并CRS患者的实用治疗方案。
尽管关于变应性鼻炎与CRS因果关系的文献存在矛盾,但近期研究表明,药物治疗无效的CRS患者中变应性鼻炎的发病率更高。推测局部IgE在这两种疾病的炎症特征中起作用,即使在吸入性过敏检测呈阴性的患者中也是如此。
由于变应性鼻炎和CRS的症状重叠,适用于一种疾病的药物可能也适用于另一种疾病。例外情况是在无过敏时的变应原免疫疗法以及无感染时的抗生素使用。基于这些原则,我们制定并提供了一种针对有变应性鼻炎和CRS症状患者的个性化管理策略,该策略基于个体对治疗的反应。