Trifina Eva, Geissler Dietmar, Zwettler Elisabeth, Klaushofer Klaus, Mikosch Peter
1. Medizinische Abteilung und Ludwig Boltzmann-Institut für Osteologie, Hanusch-Krankenhaus, Wien, Austria.
Wien Med Wochenschr. 2012 Mar;162(5-6):110-4. doi: 10.1007/s10354-012-0064-5.
A 44 yr-old female with osteoporosis had no relevant gastrointestinal symptoms and did not avoid any specific food. However, after prescription of a lactose-rich calcium supplementation, clinical symptoms suspicious for lactose intolerance occurred, which were thereafter confirmed by a lactose tolerance test. Lactose intolerance may present with only slight or subtle symptoms. Drugs containing lactose may induce or increase gastrointestinal symptoms in patients with lactose intolerance. In case of gastrointestinal symptoms occurring after the initiation of drugs containing lactose, the possibility of lactose intolerance should be considered and tested by lactose tolerance test or genetic testing for the LCT (-13910) polymorphism. Due to the prevalence of about 15-25% lactose intolerance in the Austrian population, lactose free drugs should be prescribed as widely as possible.
一名44岁患有骨质疏松症的女性没有相关的胃肠道症状，也没有忌口任何特定食物。然而，在服用富含乳糖的补钙剂后，出现了疑似乳糖不耐受的临床症状，随后通过乳糖耐量试验得到证实。乳糖不耐受可能仅表现为轻微或不明显的症状。含乳糖的药物可能会诱发或加重乳糖不耐受患者的胃肠道症状。如果在开始服用含乳糖药物后出现胃肠道症状，应考虑乳糖不耐受的可能性，并通过乳糖耐量试验或LCT（-13910）多态性基因检测进行排查。由于奥地利人群中乳糖不耐受的患病率约为15%-25%，应尽可能广泛地开具无乳糖药物。
