Department of Psychiatry, University Hospital Vall d'Hebron, Barcelona, Catalonia, Spain.
Subst Abus. 2012;33(2):186-8. doi: 10.1080/08897077.2011.634968.
There are few studies describing psychiatric symptoms occurring when methylphenidate and disulfiram are used together. The authors report a case of disulfiram and methylphenidate interaction in which psychotic symptoms could be dose dependent. The patient, diagnosed of alcohol and cocaine dependence and attention deficit hyperactivity disorder (ADHD), started treatment with methylphenidate increasing doses and disulfiram 250 mg/day over 4 weeks. During the first 2 weeks at doses of 36 mg/day of methylphenidate and maintaining disulfiram, side effects were not observed. However, by increasing to 54 mg/day, psychotic symptoms were detected. The authors reported that the effects are dose dependent. This is the first report about dose-dependent side effects in substance use disorder with ADHD.
目前鲜有研究描述哌醋甲酯和双硫仑同时使用时出现的精神症状。作者报告了 1 例双硫仑和哌醋甲酯相互作用的病例，其精神症状可能与剂量有关。该患者被诊断为酒精和可卡因依赖以及注意缺陷多动障碍（ADHD），开始使用哌醋甲酯治疗，剂量逐渐增加，同时服用双硫仑 250mg/天，共 4 周。在最初的 2 周内，哌醋甲酯剂量为 36mg/天，同时维持双硫仑治疗，未观察到副作用。然而，当剂量增加至 54mg/天时，出现了精神病症状。作者报告称，这些影响是剂量依赖性的。这是第一篇关于 ADHD 物质使用障碍中剂量依赖性副作用的报告。
