抗疟福司林生物碱的仿生合成。
Biomimetic synthesis of the antimalarial flindersial alkaloids.
机构信息
Department of Chemistry, University of Houston, 136 Fleming Building, Houston, Texas 77204-5003, USA.
出版信息
J Am Chem Soc. 2012 Apr 25;134(16):6936-9. doi: 10.1021/ja301387k. Epub 2012 Apr 10.
PMID:22489830
Abstract
A biomimetic strategy for the synthesis of the antimalarial flindersial alkaloids is described. Flinderoles A, B, and C, desmethylflinderole C, isoborreverine, and dimethylisoborreverine were all synthesized in three steps from tryptamine. The key step is an acid-promoted dimerization of the natural product borrerine. This approach is thought to mirror the biosynthesis of these compounds.
摘要
描述了一种仿生策略，用于合成抗疟弗林德斯生物碱。从色胺出发，三步即可合成弗林德斯醇 A、B 和 C、去甲弗林德斯醇 C、异博雷宁和二甲异博雷宁。关键步骤是在酸的促进下，天然产物博雷宁发生二聚反应。这种方法被认为可以模拟这些化合物的生物合成过程。
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