Li Rui-Jian, Zhao Lu-Jun, Zhan Zhong-Li, Lü Xu, Gong Lin-Lin, Wang Ping
Department of Radiotherapy, Cancer Institute & Hospital, Tianjin Medical University, Tianjin 300060, China.
Zhonghua Yi Xue Za Zhi. 2012 Feb 28;92(8):532-5.
To explore the expressions of CXC chemokine receptor 4 (CXCR4) and matrix metalloproteinase-9 (MMP-9) and examine their correlations with metastasis and prognosis in small cell lung cancer (SCLC).
Immunohistochemistry was employed to detect the expressions of CXCR4 and MMP-9 in the tissue samples from 65 SCLC patients treated in Cancer Institute and Hospital Attached to Tianjin Medical University from January 2003 to October 2009. And their correlations with metastasis and prognosis were analyzed by Chi-square test and Kaplan-Meier method and Cox regression.
The positive expression rates of CXCR4 and MMP-9 were 100.0% (65/65) and 87.7% (57/65) in SCLC tissues respectively. Significant difference of the expression rate of CXCR4 was found between patients undergoing bone metastasis or not (P = 0.004). But the differences were not significant between brain metastasis or not (P = 0.068) and lymph node metastasis or not (P = 0.085). A high expression rate of MMP-9 was significantly associated with pathological staging (P = 0.048). But the difference between lymph node metastasis or not was not significant (P = 0.085). Univariate analysis suggested that a high expression rate of CXCR4 was significantly correlated with the disease-free survival (DFS) of SCLC patients (P = 0.005). But a high expression rate of MMP-9 was not associated with DFS (P = 0.341). Multivariate analysis suggested that a high expression rate of CXCR4 was an independent prognostic factor for DFS in SCLC.
The elevated levels of CXCR4 and MMP-9 are found in SCLC tissues. And the expression rate of CXCR4 may be correlated with bone metastasis, but the correlation is not notable for MMP-9. The expression rate of CXCR4 is an independent prognostic factor for DFS in SCLC.
探讨CXC趋化因子受体4（CXCR4）和基质金属蛋白酶-9（MMP-9）在小细胞肺癌（SCLC）中的表达情况，并研究它们与转移及预后的相关性。
采用免疫组织化学法检测2003年1月至2009年10月在天津医科大学附属肿瘤医院接受治疗的65例SCLC患者组织样本中CXCR4和MMP-9的表达。通过卡方检验、Kaplan-Meier法和Cox回归分析它们与转移及预后的相关性。
SCLC组织中CXCR4和MMP-9的阳性表达率分别为100.0%（65/65）和87.7%（57/65）。发生骨转移与未发生骨转移的患者之间CXCR4表达率存在显著差异（P = 0.004）。但发生脑转移与未发生脑转移（P = 0.068）以及发生淋巴结转移与未发生淋巴结转移（P = 0.085）之间差异不显著。MMP-9高表达率与病理分期显著相关（P = 0.048）。但发生淋巴结转移与未发生淋巴结转移之间差异不显著（P = 0.085）。单因素分析表明，CXCR4高表达率与SCLC患者的无病生存期（DFS）显著相关（P = 0.005）。但MMP-9高表达率与DFS无关（P = 0.341）。多因素分析表明，CXCR4高表达率是SCLC患者DFS的独立预后因素。
SCLC组织中CXCR4和MMP-9水平升高。CXCR4表达率可能与骨转移相关，但MMP-9的相关性不明显。CXCR4表达率是SCLC患者DFS的独立预后因素。
