Department of Cardiology, Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Chin Med J (Engl). 2012 Feb;125(3):428-33.
Cardiac resynchronization therapy (CRT) with biventricular pacing improves cardiac function, functional capacity and quality of life in selected patients with heart failure. The current study aimed to evaluate the efficacy of the intracardiac electrogram (IEGM)-based optimization method, QuickOpt(TM), in Chinese patients treated with CRT.
Aortic time velocity integrals (AVTI) achieved at the sensed atrioventricular (AV), paced AV and interventricular (VV) interval settings recommended by both QuickOpt(TM) and standard echocardiographic optimization were measured in 101 patients. Consistency and the strength of the relationship between the two timing cycle optimization methods were assessed by intra-class correlation coefficient (ICC).
The ICC showed good agreement and correlation with what the AVTI achieved at the optimal sensed AV (ICC = 0.9683 (0.9535 - 0.9785)), paced AV (ICC = 0.9642 (0.9475 - 0.9757)) and VV (ICC = 0.9730 (0.9602 - 0.9817)) interval settings determined by the two optimization methods. The average time required by echocardiographic optimization and by QuickOpt(TM) were (78.32 ± 32.40) minutes and (1.98 ± 1.64) minutes respectively (P < 0.0001).
The QuickOpt(TM) algorithm provides a quicker, simpler and reliable alternative to the standard method for timing cycle optimization.
心脏再同步治疗（CRT）联合双心室起搏可改善心力衰竭患者的心脏功能、功能能力和生活质量。本研究旨在评估基于心内电图（IEGM）的优化方法QuickOpt（TM）在中国 CRT 治疗患者中的疗效。
在 101 例患者中测量基于心内电图优化的感知房室（AV）、起搏 AV 和室间（VV）间期设置时获得的主动脉速度时间积分（AVTI）。通过组内相关系数（ICC）评估两种定时循环优化方法的一致性和相关性。
ICC 显示出与两种优化方法确定的最佳感知 AV（ICC=0.9683（0.9535-0.9785））、起搏 AV（ICC=0.9642（0.9475-0.9757））和 VV（ICC=0.9730（0.9602-0.9817））间期设置时获得的 AVTI 具有良好的一致性和相关性。超声心动图优化和 QuickOpt（TM）所需的平均时间分别为（78.32±32.40）分钟和（1.98±1.64）分钟（P＜0.0001）。
QuickOpt（TM）算法为定时循环优化提供了一种更快、更简单、更可靠的标准方法替代方案。
