Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Chin Med J (Engl). 2012 Feb;125(4):646-51.
Recently, new anti-epileptic drugs (AEDs) have been more frequently selected to treat epilepsy. In the present study, we evaluated the dynamic changes of efficacy and safety of three newer AEDs for treating partial epilepsy in China.
Patients were collected sequentially and were divided into three groups which accepted oxcarbazepine (OXC), lamotrigine (LTG) or topiramate (TPM) therapy. Each group included monotherapy and add-on therapy subgroups. We followed all patients for one year and recorded the indexes of efficacy and safety in detail.
A total of 909 patients finished the follow-up observation. No significant difference was found in proportion of patients with > or = 50% reduction, > or = 75% reduction and 100% seizure reduction in the LTG and OXC groups between the first and the second six months. In the TPM group there was a statistical difference between the first and the second six months in proportion of patients with > or = 50% reduction (P = 0.002), > or = 75% reduction (P < 0.0001) and 100% seizure reduction (P = 0.009) in the monotherapy subgroup, and about > or = 75% reduction and 100% seizure reduction in the add-on therapy subgroup (P < 0.0001). The efficacy between the add-on and monotherapy subgroups showed a statistical difference. The safety of the three newer AEDs was good.
The three newer AEDs all showed good efficacy and tolerability for partial epilepsy. And the efficacy can be maintained for at least one year.
最近，新的抗癫痫药物（AEDs）越来越频繁地被选择用于治疗癫痫。在本研究中，我们评估了三种新型 AED 治疗中国部分性癫痫的疗效和安全性的动态变化。
连续收集患者，并将其分为三组，分别接受奥卡西平（OXC）、拉莫三嗪（LTG）或托吡酯（TPM）治疗。每组均包括单药治疗和添加治疗亚组。我们对所有患者进行了为期一年的随访，并详细记录了疗效和安全性指标。
共有 909 例患者完成了随访观察。LTG 组和 OXC 组在第 1 至第 6 个月和第 6 至第 12 个月之间，>或=50%缓解、>或=75%缓解和 100%癫痫发作减少的患者比例无显著差异。TPM 组单药治疗亚组第 1 至第 6 个月和第 6 至第 12 个月之间，>或=50%缓解（P=0.002）、>或=75%缓解（P<0.0001）和 100%癫痫发作减少（P=0.009）的患者比例存在统计学差异，添加治疗亚组中>或=75%缓解和 100%癫痫发作减少的患者比例也存在统计学差异（P<0.0001）。添加治疗和单药治疗亚组之间的疗效存在统计学差异。三种新型 AED 的安全性良好。
三种新型 AED 对部分性癫痫均显示出良好的疗效和耐受性，且疗效至少能维持 1 年。
