Watson N R, Studd J W
Dulwich Premenstrual Tension Clinic, King's College Hospital, London.
Br J Hosp Med. 1990 Oct;44(4):286-92.
The recognition of the relationship between premenstrual syndrome and cyclical ovarian activity has enabled the rationalization of treatment. Placebo-controlled studies have established the efficacy of treatments that alter ovarian function, therefore it should no longer be necessary to rely on the placebo effect of unproven treatments such as progesterone.
