Choi Junjeong, Kim Dokyung, Koo Ja Seung
Yonsei University Wonju College of Medicine, Wonju, South Korea.
Int J Surg Pathol. 2012 Aug;20(4):367-72. doi: 10.1177/1066896912440506. Epub 2012 Apr 4.
The aim of this study was to evaluate the pattern of p63 expression and its implication in secretory carcinoma of the breast. Immunohistochemical staining for p63, p53, MDM2, and smooth muscle actin was performed in 7 cases of secretory carcinomas. Nuclear expression of p63 was observed in 3 cases, whereas staining against cytoplasmic and intraluminal secretory material were observed in 4 cases. p53 was expressed in 3 cases and MDM2 in 2 cases. The loss of myoepithelial cells was confirmed by immunohistochemical stain for smooth muscle actin in invasive secretory carcinomas. The pattern of expression of p63 in secretory carcinoma of the breast was revealed in nuclei or cytoplasm/secretory materials.
本研究的目的是评估p63在乳腺分泌性癌中的表达模式及其意义。对7例分泌性癌进行了p63、p53、MDM2和平滑肌肌动蛋白的免疫组织化学染色。3例观察到p63核表达，4例观察到针对细胞质和管腔内分泌物质的染色。3例表达p53，2例表达MDM2。浸润性分泌性癌中通过平滑肌肌动蛋白免疫组织化学染色证实肌上皮细胞缺失。乳腺分泌性癌中p63的表达模式显示于细胞核或细胞质/分泌物质中。
