Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
J Infect Chemother. 2012 Oct;18(5):729-33. doi: 10.1007/s10156-012-0410-y. Epub 2012 Apr 11.
Pharyngeal chlamydial and gonococcal infections can occur as a consequence of oral sex, and they also can be transmitted from the pharynx to the genital tract of sex partners. There have been many reports on the prevalence of pharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae in men who have sex with men; however, there have been few reports on the prevalence of these pathogens in the pharynges of heterosexual men. In this study, we determined the prevalence of pharyngeal C. trachomatis and N. gonorrhoeae in 42 heterosexual men diagnosed with urethritis. Pharyngeal swabs and first-voided urine specimens were tested using the Gen-Probe APTIMA Combo 2 transcription-mediated amplification assay. The prevalence of pharyngeal C. trachomatis and N. gonorrhoeae in patients with urethritis was 2.4 % (1/42) and 11.9 % (5/42), respectively. Among patients with either chlamydial or gonococcal urethritis, 9.1 % (1/11) and 25.0 % (5/20) had pharyngeal C. trachomatis or N. gonorrhoeae, respectively. Our results suggest that screening for pharyngeal colonization by N. gonorrhoeae and C. trachomatis using validated nucleic acid amplification tests should be performed in heterosexual men diagnosed with urethritis.
咽淋病原体和淋病奈瑟菌感染可因口交而发生，也可从咽部分泌物传播至性伴侣的生殖道。已有许多关于男男性接触者咽部分泌物沙眼衣原体和淋病奈瑟菌流行率的报道；然而，关于异性恋男性咽部分泌物中这些病原体流行率的报道却很少。在这项研究中，我们确定了 42 例确诊为尿道炎的异性恋男性咽部分泌物中沙眼衣原体和淋病奈瑟菌的流行率。使用 Gen-Probe APTIMA Combo 2 转录介导扩增检测法对咽拭子和首次排空尿液标本进行检测。尿道炎患者咽部分泌物沙眼衣原体和淋病奈瑟菌的流行率分别为 2.4%（1/42）和 11.9%（5/42）。在有衣原体或淋病奈瑟菌尿道炎的患者中，9.1%（1/11）和 25.0%（5/20）的患者咽部分泌物中分别有沙眼衣原体或淋病奈瑟菌。我们的研究结果表明，对确诊为尿道炎的异性恋男性，应使用经验证的核酸扩增检测法筛查咽部分泌物中淋病奈瑟菌和沙眼衣原体的定植情况。
