Rickettsial Zoonoses Branch, Division of Vectorborne Infectious Diseases, National Center for Emerging and Zoonotic Infectious Disease, Atlanta, Georgia, USA.
Am J Trop Med Hyg. 2012 Apr;86(4):713-9. doi: 10.4269/ajtmh.2012.11-0453.
Death from Rocky Mountain spotted fever (RMSF) is preventable with prompt, appropriate treatment. Data from two independent sources were analyzed to estimate the burden of fatal RMSF and identify risk factors for fatal RMSF in the United States during 1999-2007. Despite increased reporting of RMSF cases to the Centers for Disease Control and Prevention, no significant changes in the estimated number of annual fatal RMSF cases were found. American Indians were at higher risk of fatal RMSF relative to whites (relative risk [RR] = 3.9), and children less than 10 years of age (RR=5.1) [corrected] and adults ≥ 70 years of age (RR = 3.0) were also at increased risk relative to other ages. Persons with cases of RMSF with an immunosuppressive condition were at increased risk of death (RR = 4.4). Delaying treatment of RMSF was also associated with increased deaths. These results may indicate a gap between recommendations and practice.
死于落矶山斑点热（RMSF）是可以预防的，如果及时和适当的治疗。分析了两个独立的来源的数据，以估计在美国 1999-2007 年期间致命 RMSF 的负担和确定致命 RMSF 的危险因素。尽管向疾病控制和预防中心报告的 RMSF 病例有所增加，但估计每年致命 RMSF 病例的数量没有显著变化。与白人相比，美洲印第安人患致命 RMSF 的风险更高（相对风险 [RR] = 3.9），10 岁以下的儿童（RR=5.1）[更正]和 70 岁以上的成年人（RR = 3.0）也比其他年龄段的人风险更高。患有免疫抑制性疾病的 RMSF 病例的人死亡风险增加（RR = 4.4）。延迟 RMSF 的治疗也与死亡人数的增加有关。这些结果可能表明建议和实践之间存在差距。
