Out-patient Clinic of Occupational Diseases, Nofer Institute of Occupational Medicine, Łódź, Poland.
Int J Occup Med Environ Health. 2012 Jun;25(2):196-9. doi: 10.2478/S13382-012-0019-5. Epub 2012 Apr 10.
Para-phenylenediamine (PPD) can induce immediate or - more often - delayed hypersensitivity. We report the case of 48-year old female admitted to the out-patient allergy clinic a day after her visit in a beauty parlour, where she had her eyelashes and eyebrows dyed with henna. Physical examination revealed prominent edema of the upper part of the face including forehead, cheeks and eyes causing severe narrowing of the palpebral chink. Skin prick tests (SPT) with common allergens were positive for Dermatophagoides pteronyssinus, Dermatophagoides farinae and moulds, while the SPT with PPD was negative. Patch test to PPD was positive. Further investigations revealed eosinophilia in the tear fluid. To our knowledge, this is the first case of PPD-induced contact blepharoconjunctivitis (CB) with concomitant increased eosinophilia in the tear fluid.
对苯二胺(PPD)可引起即刻或 - 更常见 - 迟发性超敏反应。我们报告了一例 48 岁女性的病例,她在去美容院染了睫毛和眉毛一天后,因在美容院染了睫毛和眉毛而到过敏门诊就诊。体格检查显示上半部分面部明显肿胀,包括额头、脸颊和眼睛,导致睑裂严重变窄。皮肤点刺试验(SPT)对尘螨、屋尘螨和霉菌呈阳性,而 PPD 的 SPT 呈阴性。PPD 斑贴试验阳性。进一步的调查显示泪液中的嗜酸性粒细胞增多。据我们所知,这是首例 PPD 引起的接触性睑结膜炎(CB)伴泪液中嗜酸性粒细胞增多的病例。