Department of Otolaryngology, Konkuk University School of Medicine, Chungju, Korea.
Otolaryngol Head Neck Surg. 2012 Aug;147(2):239-44. doi: 10.1177/0194599812444269. Epub 2012 Apr 6.
Tutoplast-processed fascia lata (TPFL) is a commercially available homograft that has been successfully used as graft tissue for rhinoplasty. The present study evaluates the histomorphological changes of TPFL in a rabbit rhinoplasty model.
Prospective study using a rabbit model.
Animal laboratory of the Asan Medical Center.
The study used 15 New Zealand White rabbits. Each rabbit was implanted with a TPFL (experimental group) and autologous fascia lata (control group) graft of equal size into the nasal dorsum. Rabbits were killed at 1, 3, and 6 months, and the grafts were removed and microscopically assessed for fibroblast proliferation, neovascularization, inflammation, and thickness.
For TPFL grafts, the degree of inflammation significantly decreased between 1 and 3 months (P = .041). The degree of fibroblast proliferation continually increased over time. There was a mild degree of neovascularization for the TPFL graft at 1 month. The degree of neovascularization increased between 3 and 6 months (P = .041). For the degree of inflammation, fibroblast proliferation, and neovascularization, there was no significant difference between TPFL and autologous fascia lata at 6 months. Mean thickness analysis showed that there was no significant thickness reduction in both TPFL and autologous fascia lata grafts at 6 months.
The TPFL grafts showed negligible resorption rates and favorable tissue reactions in the rabbit rhinoplasty model.
经 Tutoplast 处理的阔筋膜（TPFL）是一种市售同种异体移植物，已成功用作鼻整形术的移植物组织。本研究评估了 TPFL 在兔鼻整形模型中的组织形态学变化。
使用兔模型的前瞻性研究。
延世医疗中心动物实验室。
本研究使用了 15 只新西兰白兔。每只兔子的鼻背都植入了大小相等的 TPFL（实验组）和自体阔筋膜（对照组）移植物。兔子在 1、3 和 6 个月时被处死，取出移植物并进行显微镜评估，以评估成纤维细胞增殖、新生血管形成、炎症和厚度。
对于 TPFL 移植物，1 至 3 个月时炎症程度显著降低（P =.041）。成纤维细胞增殖随时间持续增加。1 个月时 TPFL 移植物有轻度新生血管形成。3 至 6 个月间，新生血管形成程度增加（P =.041）。在炎症程度、成纤维细胞增殖和新生血管形成方面，6 个月时 TPFL 和自体阔筋膜之间没有显著差异。平均厚度分析显示，6 个月时 TPFL 和自体阔筋膜移植物均无明显厚度减少。
TPFL 移植物在兔鼻整形模型中显示出可忽略的吸收率和良好的组织反应。
