新型金刚烷基三肽的合成及免疫刺激特性。
Synthesis and immunostimulating properties of novel adamant-1-yl tripeptides.
机构信息
Department of Chemistry, University of Zagreb, Zagreb, Croatia.
出版信息
Chem Biodivers. 2012 Apr;9(4):777-88. doi: 10.1002/cbdv.201100232.
The aim of this work was to prepare L- and D-(adamant-1-yl)-Gly-L-Ala-D-isoGln peptides in order to study their adjuvant (immunostimulating) activities. Adjuvant activity of adamant-1-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM; β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH(2) )-D-Ala-D-Ala) and structurally related adamant-2-yl tripeptides.
这项工作的目的是制备 L-和 D-（金刚烷-1-基）-Gly-L-Ala-D-异谷氨酰胺肽，以研究它们的佐剂（免疫刺激）活性。使用卵清蛋白作为抗原，在小鼠模型中测试了金刚烷-1-基三肽的佐剂活性，并与肽聚糖单体（PGM；β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-异谷氨酰胺-mesoDAP(εNH(2) )-D-Ala-D-Ala）和结构相关的金刚烷-2-基三肽进行了比较。
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