[Spophylin Spofa--tablets with a delayed effect: therapeutic use in the complex therapy of acute bronchitis in infants and toddlers].

In 18 children aged 6-36 months with acute respiratory disease and bronchospasms the authors administered as part of comprehensive treatment Spophyllin tablets with a retarded effect (16-20 mg/kg/hours). Concurrently the theophyllin serum and saliva levels were assessed on the third day of administration. The authors proved a direct relationship between serum and saliva levels. The assessed values in saliva accounted on average for 73.5% of the serum levels. Values in saliva (6-7 micrograms/l ml) were indicators of effective serum values.