Department of Engineering Sciences, Division of Applied Materials Science, The Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Biomed Mater. 2012 Jun;7(3):035013. doi: 10.1088/1748-6041/7/3/035013. Epub 2012 Apr 11.
One of the major issues with the currently available injectable biomaterials for hard tissue replacement is the mismatch between their mechanical properties and those of the surrounding bone. Hybrid bone cements that combine the benefits of tough polymeric and bioactive ceramic materials could become a good alternative. In this work, polyhedral oligomeric silsesquioxane (POSS) was copolymerized with poly(ethylene glycol) (PEG) to form injectable in situ cross-linkable hybrid cements. The hybrids were characterized in terms of their mechanical, rheological, handling and in vitro bioactive properties. The results indicated that hybridization improves the mechanical and bioactive properties of POSS and PEG. The Young moduli of the hybrids were lower than those of commercial cements and more similar to those of cancellous bone. Furthermore, the strength of the hybrids was similar to that of commercial cements. Calcium deficient hydroxyapatite grew on the surface of the hybrids after 28 days in PBS, indicating bioactivity. The study showed that PEG-POSS-based hybrid materials are a promising alternative to commercial bone cements.
目前可用于硬组织替代的注射用生物材料的主要问题之一是其机械性能与周围骨骼的不匹配。结合了坚韧的聚合物和生物活性陶瓷材料优点的混合骨水泥可能成为一种很好的替代品。在这项工作中，多面体低聚倍半硅氧烷（POSS）与聚乙二醇（PEG）共聚形成可注射的原位交联混合水泥。根据机械、流变、处理和体外生物活性特性对混合物进行了表征。结果表明，杂化可以提高 POSS 和 PEG 的机械和生物活性性能。混合物的杨氏模量低于商用水泥，更接近松质骨。此外，混合物的强度与商用水泥相似。在 PBS 中培养 28 天后，在混合物表面长出了缺钙羟基磷灰石，表明具有生物活性。该研究表明，基于 PEG-POSS 的混合材料是商用骨水泥的一种有前途的替代品。
