Department of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Anticancer Res. 2012 Apr;32(4):1417-22.
BACKGROUND/AIM: Hepatectomy without recurrence for more than five years may be considered as being a sufficient resection of primary hepatocellular carcinoma (HCC). The purpose of the present study was to clarify the predictive factors for sufficient resection for HCC patients.
In our Department, 77 patients with HCC survived without recurrence for more than five years following hepatectomy (curative group) and 187 patients underwent hepatectomy but developed recurrence within five years (recurrence group). We compared the clinicopathology between these two groups and evaluated the favorable factors for HCC without recurrence using logistic regression analysis.
The curative group was associated with three independent factors by multivariate logistic regression analyses: tumor size, serum indocyanine green retention rate (ICG15) and anatomic wide hepatectomy (all p<0.05).
Sufficient resection is closely related to patient, tumor, and treatment factors. Anatomic wide hepatectomy for small (<29 mm) HCC in patients with sufficient liver function (ICG15 <16.5%) can achieve sufficient resection.
背景/目的：无复发生存超过五年的肝癌切除术可被视为原发性肝癌（HCC）的充分切除术。本研究的目的是阐明 HCC 患者充分切除的预测因素。
在我院，77 例 HCC 患者行肝切除术后无复发且存活超过五年（治愈组），187 例患者行肝切除术但在五年内复发（复发组）。我们比较了两组的临床病理特征，并通过逻辑回归分析评估了 HCC 无复发的有利因素。
多因素逻辑回归分析显示，治愈组与三个独立因素相关：肿瘤大小、血清吲哚菁绿滞留率（ICG15）和解剖性广泛肝切除术（均 p<0.05）。
充分切除与患者、肿瘤和治疗因素密切相关。对于肝功能充足（ICG15<16.5%）的小 HCC（<29mm）患者，进行解剖性广泛肝切除术可实现充分切除。
