Kong Xiaoni, Horiguchi Norio, Mori Masatomo, Gao Bin
Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Bethesda, MD, USA.
Front Physiol. 2012 Apr 3;3:69. doi: 10.3389/fphys.2012.00069. eCollection 2012.
Liver fibrosis, or cirrhosis, is a common end-stage condition of many chronic liver diseases after incomplete recovery from hepatocyte damage. During fibrosis progression, hepatocellular damage and inflammation trigger complex cellular events that result in collagen deposition and the disruption of the normal liver architecture. Hepatic stellate cell activation and transdifferentiation into myofibroblasts are key events in liver fibrogenesis. Research findings from cell culture and animal models have revealed that the Janus kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway, which can be activated by many cytokines, growth factors, and hormones, plays a critical role in hepatic fibrogenesis. This review summarizes the biological significance of diverse cytokines and their downstream signaling protein STATs in hepatic fibrogenesis.
肝纤维化或肝硬化是许多慢性肝病在肝细胞损伤后未完全恢复的常见终末期病症。在纤维化进展过程中，肝细胞损伤和炎症引发复杂的细胞事件，导致胶原蛋白沉积和正常肝脏结构的破坏。肝星状细胞激活并转分化为肌成纤维细胞是肝纤维化发生过程中的关键事件。细胞培养和动物模型的研究结果表明，可被多种细胞因子、生长因子和激素激活的Janus激酶-信号转导子和转录激活子（Jak-STAT）信号通路在肝纤维化发生中起关键作用。本综述总结了多种细胞因子及其下游信号蛋白STATs在肝纤维化发生中的生物学意义。
