癌症治疗的分层医学。

Stratified medicine for cancer therapy.

机构信息

Cancer Research UK, London, UK.

出版信息

Drug Discov Today. 2012 Mar;17(5-6):261-8. doi: 10.1016/j.drudis.2012.02.004.

DOI:10.1016/j.drudis.2012.02.004

Abstract

As knowledge of the biological processes underlying malignant transformation becomes increasingly sophisticated, apparently similar diseases can be redefined according to the critical disrupted biological pathways and networks. The key genetic changes in most cancers can be mapped to one of a relatively few pathways, making it possible to classify tumours by their abnormal pathways and to identify potentially treatable--'druggable'--targets within these. The aim of the stratified approach to cancer therapy is to improve the effectiveness, tolerability and affordability of novel therapeutic agents.

摘要

随着对恶性转化背后的生物学过程的认识日益复杂，根据关键的失调生物学途径和网络，显然相似的疾病可以被重新定义。大多数癌症的关键遗传变化可以映射到相对较少的途径之一，这使得通过其异常途径对肿瘤进行分类并识别这些途径中潜在的可治疗（“可用药”）靶点成为可能。癌症治疗分层方法的目的是提高新型治疗剂的有效性、耐受性和可负担性。