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In vivo testing of 177Lu-labelled anti-PSMA antibody as a new radioimmunotherapeutic agent against prostate cancer.177Lu 标记的抗 PSMA 抗体作为针对前列腺癌的新型放射性免疫治疗药物的体内测试。
In Vivo. 2011 Jan-Feb;25(1):55-9.
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Biochemical characterization and mapping of the 7E11-C5.3 epitope of the prostate-specific membrane antigen.前列腺特异性膜抗原7E11-C5.3表位的生化特性鉴定与定位
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Preclinical evaluation of a recombinant anti-prostate specific membrane antigen single-chain immunotoxin against prostate cancer.抗前列腺特异性膜抗原单链免疫毒素对前列腺癌的临床前评价。
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Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects.通过 EPR 效应实现大分子药物的肿瘤选择性递送：背景与未来展望。
Bioconjug Chem. 2010 May 19;21(5):797-802. doi: 10.1021/bc100070g.
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Docetaxel-based combination therapy for castration-resistant prostate cancer.多西他赛为基础的联合治疗用于去势抵抗性前列腺癌。
Ann Oncol. 2010 Nov;21(11):2135-2144. doi: 10.1093/annonc/mdq050. Epub 2010 Mar 29.
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Molecular and traditional chemotherapy: a united front against prostate cancer.分子和传统化疗：联合对抗前列腺癌。
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Preclinical evaluation of a monoclonal antibody (3C6) specific for prostate-specific membrane antigen.针对前列腺特异性膜抗原的单克隆抗体（3C6）的临床前评估
Curr Radiopharm. 2009 Jan;2(1):9-17. doi: 10.2174/1874471010902010009.
8
Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities.HPMA 共聚物缀合物是否有作为临床有用的纳米药物的未来？对当前现状和未来机遇的批判性综述。
Adv Drug Deliv Rev. 2010 Feb 17;62(2):272-82. doi: 10.1016/j.addr.2009.12.005. Epub 2009 Dec 11.
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Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations.利用 HPMA 共聚物纳米药物制剂提高联合抗癌疗法的疗效。
Adv Drug Deliv Rev. 2010 Feb 17;62(2):203-30. doi: 10.1016/j.addr.2009.11.028. Epub 2009 Dec 4.
10
Three conformational antibodies specific for different PSMA epitopes are promising diagnostic and therapeutic tools for prostate cancer.三种针对不同 PSMA 表位的构象抗体是前列腺癌有前途的诊断和治疗工具。
Prostate. 2010 Apr 1;70(5):562-9. doi: 10.1002/pros.21090.

前列腺癌靶向 N-(2-羟丙基)甲基丙烯酰胺共聚物/多西他赛缀合物。

Prostate-cancer-targeted N-(2-hydroxypropyl)methacrylamide copolymer/docetaxel conjugates.

机构信息

Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD, University of Utah, Salt Lake City, UT 84112, USA.

出版信息

Macromol Biosci. 2012 Mar;12(3):412-22. doi: 10.1002/mabi.201100340.

DOI:10.1002/mabi.201100340
PMID:22493797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4605348/
Abstract

Biodistribution, pharmacokinetics, and efficacy of prostate-cancer-targeted HPMA copolymer/DTX conjugates are evaluated in nude mice bearing prostate cancer C4-2 xenografts. PSMA-specific monoclonal antibodies 3F/11 are used as the targeting moiety. Control conjugates tumor accumulation to total background organs (heart, lung, kidney, liver, spleen and blood) accumulation increase substantially with time for the targeted conjugate, and the ratio at 48 h is 7-fold higher than that at 6 h. Preliminary evaluation of the efficacy of the conjugates in vivo show tumor growth inhibition for all HPMA copolymer/DTX conjugates.

摘要

在荷前列腺癌 C4-2 移植瘤 nude 小鼠中评价了前列腺癌靶向 HPMA 共聚物/多西紫杉醇偶联物的生物分布、药代动力学和疗效。PSMA 特异性单克隆抗体 3F/11 用作靶向部分。与靶向偶联物相比，对照偶联物的肿瘤积累到总背景器官（心、肺、肾、肝、脾和血液）的积累随时间显著增加，48 h 的比值是 6 h 的 7 倍。体内偶联物疗效的初步评价表明，所有 HPMA 共聚物/多西紫杉醇偶联物均能抑制肿瘤生长。