Townsville Hospital, Townsville, Queensland 4814, Australia.
Diagn Microbiol Infect Dis. 2012 May;73(1):27-30. doi: 10.1016/j.diagmicrobio.2012.02.010. Epub 2012 Apr 10.
The measurement of cerebrospinal fluid (CSF) protein, glucose, and white cell count (WCC) is an essential part of the initial examination of CSF. The aim of this study was to determine the utility of CSF parameters in assessing the likely aetiological agent. A total of 2290 CSF samples from a 13-year period were retrospectively reviewed. The initial parameters were compared between bacterial, viral, and cryptococcal meningitis and cases where no pathogen was found. A protein concentration of <600 mg/L and a WCC <90 × 10(6)/L were found to be optimal cut-offs for excluding bacterial meningitis. A WCC of <25 × 10(6)/L was found to be optimal for excluding cryptococcal meningitis and a WCC of <10 × 10(6) for excluding viral meningitis. Decreased glucose concentration was found to be a poor indicator of the aetiological agent.
对脑脊液（CSF）蛋白、葡萄糖和白细胞计数（WCC）的测量是 CSF 初步检查的重要组成部分。本研究旨在确定 CSF 参数在评估可能的病因方面的效用。对 13 年间的 2290 例 CSF 样本进行了回顾性分析。比较了细菌、病毒和隐球菌性脑膜炎以及未发现病原体的病例之间的初始参数。发现蛋白浓度<600mg/L 和 WCC<90×10(6)/L 是排除细菌性脑膜炎的最佳截断值。WCC<25×10(6)/L 是排除隐球菌性脑膜炎的最佳截断值，WCC<10×10(6)/L 是排除病毒性脑膜炎的最佳截断值。葡萄糖浓度降低被发现是病因的不良指标。
