Cointet Jean-Philippe, Mogoutov Andrei, Bourret Pascale, El Abed Rim, Cambrosio Alberto
Institut francilien recherche innovation société/université Paris-Est Marnela-Vallée, Champs-sur-Marne, France.
Med Sci (Paris). 2012 Mar;28 Spec No 1:7-13. doi: 10.1051/medsci/2012281s104. Epub 2012 Apr 9.
This paper examines the emergence and development of one of the key components of genomics, namely gene expression profiling. It does so by resorting to computer-based methods to analyze and visualize networks of scientific publications. Our results show the central role played by oncology in this domain, insofar as the initial proof-of-principle articles based on a plant model organism have quickly led to the demonstration of the value of these techniques in blood cancers and to applications in the field of solid tumors, and in particular breast cancer. The article also outlines the essential role played by novel bioinformatics and biostatistical tools in the development of the domain. These computational disciplines thus qualify as one of the three corners (in addition to the laboratory and the clinic) of the translational research triangle.
本文探讨了基因组学的关键组成部分之一——基因表达谱分析的出现与发展。通过借助基于计算机的方法来分析和可视化科学出版物网络进行此项研究。我们的结果表明，肿瘤学在该领域发挥着核心作用，因为基于植物模式生物的初步原理验证文章迅速促成了这些技术在血癌中的价值证明以及在实体瘤领域，尤其是乳腺癌中的应用。本文还概述了新型生物信息学和生物统计学工具在该领域发展中所起的重要作用。因此，这些计算学科堪称转化研究三角（除实验室和临床之外）的三个角之一。
